Activation of EP2 receptors by PGE2 immunoregulates classically activated microglia
نویسندگان
چکیده
Background: Microglial activation contributes strongly to brain inflammation. Results: The modulation of microglial cyclooxygenase-2, iNOS and cytokine production by EP2 (PTGER2) activation is not blocked by a protein kinase A antagonist, but is mimicked by an Epac agonist. Conclusion: Epac signaling pathways prominently contribute to the modulation of microglial activation by EP2. Significance: EP2 and Epac represent potential immunomodulatory targets during brain inflammation.
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